癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
P2RX1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P51575 |
| Other Accession | P47824, P51576, NP_002549.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44980 Da |
| Antigen Region | 345-372 aa |
| Gene ID | 5023 |
|---|---|
| Other Names | P2X purinoceptor 1, P2X1, ATP receptor, Purinergic receptor, P2RX1, P2X1 |
| Target/Specificity | This P2RX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-372 amino acids from the C-terminal region of human P2RX1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | P2RX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | P2RX1 |
|---|---|
| Synonyms | P2X1 |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (PubMed:10440098, PubMed:15056721, PubMed:20699225, PubMed:8834001, PubMed:8961184). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (PubMed:14699168). Plays a role a role in urogenital, immune and cardiovascular function (By similarity). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (By similarity). In addition, contributes to smooth muscle contractions of the urinary bladder (By similarity). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (By similarity). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Detected at plasma membrane lipid rafts. |
| Tissue Location | Expressed on neutrophils and platelets (PubMed:19635923). Expressed on urinary bladder smooth muscle (PubMed:8834001). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
REFERENCES
Allsopp, R.C., et al. J. Biol. Chem. 285(43):32770-32777(2010)
Harper, M.T., et al. J. Thromb. Haemost. 8(7):1604-1613(2010)
Lalo, U., et al. J. Neurochem. 113(5):1177-1187(2010)
Varani, K., et al. Cell. Physiol. Biochem. 25 (2-3), 325-336 (2010) :
Corriden, R., et al. Sci Signal 3 (104), RE1 (2010) :
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