癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RCBTB1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NDN9 |
| Other Accession | NP_060661.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58252 Da |
| Antigen Region | 350-377 aa |
| Gene ID | 55213 |
|---|---|
| Other Names | RCC1 and BTB domain-containing protein 1, Chronic lymphocytic leukemia deletion region gene 7 protein, CLL deletion region gene 7 protein, Regulator of chromosome condensation and BTB domain-containing protein 1, RCBTB1, CLLD7, E45 |
| Target/Specificity | This RCBTB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-377 amino acids from the Central region of human RCBTB1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RCBTB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RCBTB1 |
|---|---|
| Synonyms | CLLD7, E4.5 |
| Function | May be involved in cell cycle regulation by chromatin remodeling. |
| Cellular Location | Nucleus. |
| Tissue Location | Ubiquitously expressed (PubMed:11306461, PubMed:27486781). In the retina, present in the nerve fiber layer and to a lesser extent in the inner and outer plexiform layers (at protein level) (PubMed:27486781). |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.
REFERENCES
Genuneit, J., et al. Clin. Exp. Allergy 39(12):1875-1888(2009)
Guo, D.F., et al. J. Biol. Chem. 279(20):21109-21120(2004)
Dunham, A., et al. Nature 428(6982):522-528(2004)
Solomou, E.E., et al. Leuk. Lymphoma 44(9):1579-1585(2003)
Mabuchi, H., et al. Cancer Res. 61(7):2870-2877(2001)
终于等到您。ABCEPTA（百远生物）抗体产品。
点击下方“我要评价 ”按钮提交您的反馈信息，您的反馈和评价是我们最宝贵的财富之一,
我们将在1-3个工作日内处理您的反馈信息。
如有疑问，联系：0512-88856768 tech-china@abcepta.com.
