癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
UBE2Z Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9H832 |
| Other Accession | Q6PCF7, Q3B7D1, Q3UE37, NP_075567.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 38210 Da |
| Antigen Region | 284-310 aa |
| Gene ID | 65264 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 Z, Uba6-specific E2 conjugating enzyme 1, Use1, Ubiquitin carrier protein Z, Ubiquitin-protein ligase Z, UBE2Z |
| Target/Specificity | This UBE2Z antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284-310 amino acids from the C-terminal region of human UBE2Z. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | UBE2Z Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | UBE2Z |
|---|---|
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Widely expressed. Highly in placenta, pancreas, spleen and testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE2Z is an E2 enzyme (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM].
REFERENCES
Gu, X., et al. Mol. Biol. Rep. 34(3):183-188(2007)
Jin, J., et al. Nature 447(7148):1135-1138(2007)
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