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KLHL2 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | O95198 |
| Other Accession | F1LZF0, Q8JZP3, NP_001154993.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 65975 Da |
| Antigen Region | 77-103 aa |
| Gene ID | 11275 |
|---|---|
| Other Names | Kelch-like protein 2, Actin-binding protein Mayven, KLHL2 |
| Target/Specificity | This KLHL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-103 amino acids from the N-terminal region of human KLHL2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KLHL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KLHL2 {ECO:0000303|PubMed:23838290, ECO:0000312|HGNC:HGNC:6353} |
|---|---|
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:23838290). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (PubMed:23838290). Plays a role in the reorganization of the actin cytoskeleton (PubMed:10397770). Promotes growth of cell projections in oligodendrocyte precursors (PubMed:15715669). |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8JZP3}. Cell projection. Cell projection, lamellipodium {ECO:0000250|UniProtKB:F1LZF0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8JZP3}. Note=A proportion colocalizes with the actin cytoskeleton (PubMed:10397770). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity) {ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:10397770} |
| Tissue Location | Ubiquitous. Detected throughout the brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
KLHL2 may play a role in organizing the actin cytoskeleton of the brain cells.
REFERENCES
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Williams, S.K., et al. J. Neurosci. Res. 81(5):622-631(2005)
Bu, X., et al. Oncogene 24(14):2398-2409(2005)
Soltysik-Espanola, M., et al. Mol. Biol. Cell 10(7):2361-2375(1999)
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