癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CALCRL Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P-Leica, WB, E |
|---|---|
| Primary Accession | Q16602 |
| Other Accession | Q8WN93, NP_005786.1 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52979 Da |
| Antigen Region | 340-367 aa |
| Gene ID | 10203 |
|---|---|
| Other Names | Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL, CGRPR |
| Target/Specificity | This CALCRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-367 amino acids from the Central region of human CALCRL. |
| Dilution | IHC-P-Leica~~N/A WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CALCRL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CALCRL (HGNC:16709) |
|---|---|
| Synonyms | CGRPR |
| Function | G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs) (PubMed:32296767, PubMed:33602864, PubMed:8626685). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2 (PubMed:33602864). Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2) (PubMed:32296767, PubMed:9620797). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32296767, PubMed:8626685). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Predominantly expressed in the lung and heart. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 392(3):380-385(2010)
Chang, C.L., et al. J. Biol. Chem. 285(2):1075-1080(2010)
Barwell, J., et al. Peptides 31(1):170-176(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
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