癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PVRL4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q96NY8 |
| Other Accession | NP_112178.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55454 Da |
| Antigen Region | 239-266 aa |
| Gene ID | 81607 |
|---|---|
| Other Names | Nectin-4, Ig superfamily receptor LNIR, Poliovirus receptor-related protein 4, Processed poliovirus receptor-related protein 4, PVRL4, LNIR, PRR4 |
| Target/Specificity | This PVRL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the Central region of human PVRL4. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PVRL4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NECTIN4 (HGNC:19688) |
|---|---|
| Synonyms | LNIR, PRR4, PVRL4 |
| Function | Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with AFDN at cadherin- based adherens junctions (PubMed:11544254) |
| Tissue Location | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Poliovirus receptor-like proteins (PVRLs), such as PVRL4, are adhesion receptors of the immunoglobulin superfamily and function in cell-cell adhesion (Reymond et al., 2001 [PubMed 11544254]).
REFERENCES
Derycke, M.S., et al. Am. J. Clin. Pathol. 134(5):835-845(2010)
Brancati, F., et al. Am. J. Hum. Genet. 87(2):265-273(2010)
Takano, A., et al. Cancer Res. 69(16):6694-6703(2009)
Fabre-Lafay, S., et al. BMC Cancer 7, 73 (2007) :
Fabre-Lafay, S., et al. J. Biol. Chem. 280(20):19543-19550(2005)
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