癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NPNT Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q6UXI9 |
| Other Accession | NP_001028219.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61907 Da |
| Antigen Region | 365-392 aa |
| Gene ID | 255743 |
|---|---|
| Other Names | Nephronectin, Preosteoblast EGF-like repeat protein with MAM domain, Protein EGFL6-like, NPNT, EGFL6L, POEM |
| Target/Specificity | This NPNT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 365-392 amino acids from the Central region of human NPNT. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NPNT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPNT |
|---|---|
| Synonyms | EGFL6L, POEM |
| Function | Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity). |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Note=Trapped on the cell surface or in the extracellular matrix. |
| Tissue Location | Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
REFERENCES
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)
Kahai, S., et al. PLoS ONE 4 (10), E7535 (2009) :
Huang, J.T., et al. Int. J. Mol. Med. 15(4):719-724(2005)
Brandenberger, R., et al. J. Cell Biol. 154(2):447-458(2001)
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