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GPR83 Antibody (N-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NYM4 |
| Other Accession | NP_057624.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48339 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 10888 |
|---|---|
| Other Names | Probable G-protein coupled receptor 83, G-protein coupled receptor 72, GPR83, GPR72, KIAA1540 |
| Target/Specificity | This GPR83 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GPR83. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR83 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GPR83 (HGNC:4523) |
|---|---|
| Function | G protein-coupled peptide receptor (PubMed:27117253, PubMed:37689599). Several peptides, PEN, derived from the proSAAS precursor (encoded by PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B have been reported to activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways (PubMed:27117253, PubMed:32713278, PubMed:36853120, PubMed:37689599). However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain (PubMed:36853120, PubMed:37894796). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731} |
| Tissue Location | Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPR83 is an orphan receptor. Could be a neuropeptide Y receptor.
REFERENCES
Hansen, W., et al. Genes Immun. 11(4):357-361(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hansen, W., et al. J. Immunol. 177(1):209-215(2006)
Parker, R., et al. Biochim. Biophys. Acta 1491 (1-3), 369-375 (2000) :
De Moerlooze, L., et al. Cytogenet. Cell Genet. 90 (1-2), 146-150 (2000) :
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