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GPR83 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NYM4 |
| Other Accession | NP_057624.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 48339 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 10888 |
|---|---|
| Other Names | Probable G-protein coupled receptor 83, G-protein coupled receptor 72, GPR83, GPR72, KIAA1540 |
| Target/Specificity | This GPR83 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GPR83. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GPR83 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPR83 (HGNC:4523) |
|---|---|
| Function | G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731} |
| Tissue Location | Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GPR83 is an orphan receptor. Could be a neuropeptide Y receptor.
REFERENCES
Hansen, W., et al. Genes Immun. 11(4):357-361(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hansen, W., et al. J. Immunol. 177(1):209-215(2006)
Parker, R., et al. Biochim. Biophys. Acta 1491 (1-3), 369-375 (2000) :
De Moerlooze, L., et al. Cytogenet. Cell Genet. 90 (1-2), 146-150 (2000) :
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Cat# AP18225a
