癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GPR83 Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9NYM4 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 48339 Da |
| Gene ID | 10888 |
|---|---|
| Other Names | GPR72; KIAA1540; Probable G-protein coupled receptor 83; G-protein coupled receptor 72 |
| Target/Specificity | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR83. The exact sequence is proprietary. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GPR83 (HGNC:4523) |
|---|---|
| Function | G protein-coupled peptide receptor (PubMed:27117253, PubMed:37689599). Several peptides, PEN, derived from the proSAAS precursor (encoded by PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B have been reported to activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways (PubMed:27117253, PubMed:32713278, PubMed:36853120, PubMed:37689599). However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain (PubMed:36853120, PubMed:37894796). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P30731}; Multi-pass membrane protein. Note=Colocalizes with GPR171 in the paraventricular nucleus. Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus. {ECO:0000250|UniProtKB:P30731} |
| Tissue Location | Highly expressed in the brain and spinal cord, and found in lower concentrations in the thymus and other tissues |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Parker R.,et al.Biochim. Biophys. Acta 1491:369-375(2000).
Nagase T.,et al.DNA Res. 7:143-150(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kaighin V.A.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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¥ 1,250.00
Cat# AP51243
