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DRAM Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 14 - DRAM Antibody (N-term) AP1825a
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with *DRAM antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 1 - DRAM Antibody (N-term) AP1825a
    Western blot analysis of anti-DRAM Antibody (N-term) (Cat.#AP1825a) in HepG2 cell line lysates (35ug/lane). DRAM (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, WB, E
Primary Accession Q8N682
Other Accession Q9DC58
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 26253 Da
Additional Information
Gene ID 55332
Other Names DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1, DRAM
Target/Specificity This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human DRAM.
Dilution IHC-P~~1:100~500
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDRAM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DRAM1
Synonyms DRAM
Function Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
Cellular Location Lysosome membrane; Multi-pass membrane protein
Research Areas

BACKGROUND

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.

REFERENCES

Kerley-Hamilton,J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007) Crighton,D., Autophagy 3 (1), 72-74 (2007) Crighton,D., Cell 126 (1), 121-134 (2006) Green,D.R., Cell 126 (1), 30-32 (2006)

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