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|Application ||IHC-P, WB, E|
|Calculated MW||26253 Da|
|Other Names||DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1, DRAM|
|Target/Specificity||This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human DRAM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DRAM Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.|
|Cellular Location||Lysosome membrane; Multi-pass membrane protein|
Provided below are standard protocols that you may find useful for product applications.
This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
Kerley-Hamilton,J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007) Crighton,D., Autophagy 3 (1), 72-74 (2007) Crighton,D., Cell 126 (1), 121-134 (2006) Green,D.R., Cell 126 (1), 30-32 (2006)