癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DRAM Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q8N682 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 26253 Da |
| Antigen Region | 176-206 aa |
| Gene ID | 55332 |
|---|---|
| Other Names | DNA damage-regulated autophagy modulator protein 1, Damage-regulated autophagy modulator, DRAM1, DRAM |
| Target/Specificity | This DRAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176~206 amino acids from the C-terminal region of human DRAM. |
| Dilution | IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DRAM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DRAM1 |
|---|---|
| Synonyms | DRAM |
| Function | Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. |
| Cellular Location | Lysosome membrane; Multi-pass membrane protein |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
DRAM is regulated as part of the p53 tumor suppressor pathway. It is a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this protein is associated with various tumors.
REFERENCES
Kerley-Hamilton,J.S., Biochim. Biophys. Acta 1769 (4), 209-219 (2007)
Crighton,D., Autophagy 3 (1), 72-74 (2007)
Crighton,D., Cell 126 (1), 121-134 (2006)
Green,D.R., Cell 126 (1), 30-32 (2006)
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