癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
OSTM1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q86WC4 |
| Other Accession | Q8BGT0, NP_054747.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37257 Da |
| Antigen Region | 292-321 aa |
| Gene ID | 28962 |
|---|---|
| Other Names | Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit, OSTM1, GL |
| Target/Specificity | This OSTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-321 amino acids from the C-terminal region of human OSTM1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | OSTM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | OSTM1 |
|---|---|
| Synonyms | GL |
| Function | Required for osteoclast and melanocyte maturation and function. |
| Cellular Location | Lysosome membrane; Single-pass type I membrane protein Note=Requires CLCN7 to travel to lysosomes |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.
REFERENCES
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Mazzolari, E., et al. Am. J. Hematol. 84(8):473-479(2009)
Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)
Feigin, M.E., et al. Cell. Signal. 20(5):949-957(2008)
Maranda, B., et al. J. Bone Miner. Res. 23(2):296-300(2008)
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