癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EDA2R Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9HAV5 |
| Other Accession | NP_068555.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32759 Da |
| Antigen Region | 267-297 aa |
| Gene ID | 60401 |
|---|---|
| Other Names | Tumor necrosis factor receptor superfamily member 27, X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, TNFRSF27, XEDAR |
| Target/Specificity | This EDA2R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-297 amino acids from the C-terminal region of human EDA2R. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EDA2R Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EDA2R |
|---|---|
| Synonyms | TNFRSF27, XEDAR |
| Function | Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. |
| Cellular Location | Membrane; Single-pass type III membrane protein. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Multiple alternatively spliced transcript variants have been found for this gene, but some variants lack sufficient support. [provided by RefSeq].
REFERENCES
Brockschmidt, F.F., et al. Br. J. Dermatol. 162(4):899-903(2010)
Tanikawa, C., et al. Oncogene 28(34):3081-3092(2009)
Fujimoto, A., et al. J. Hum. Genet. 54(8):461-465(2009)
Hillmer, A.M., et al. Hum. Genet. 126(2):255-264(2009)
Richards, J.B., et al. Nat. Genet. 40(11):1282-1284(2008)
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