癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
GRWD1 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BQ67 |
| Other Accession | NP_113673.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49419 Da |
| Antigen Region | 183-209 aa |
| Gene ID | 83743 |
|---|---|
| Other Names | Glutamate-rich WD repeat-containing protein 1, GRWD1, GRWD, KIAA1942, WDR28 |
| Target/Specificity | This GRWD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-209 amino acids from the Central region of human GRWD1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GRWD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GRWD1 |
|---|---|
| Synonyms | GRWD, KIAA1942, WDR28 |
| Function | Histone binding protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness (PubMed:25990725). Plays a role in ribosomal biogenesis (PubMed:15885502). |
| Cellular Location | Nucleus, nucleolus. Nucleus. Chromosome Note=Present in the nucleus throughout interphase and is detached from chromatin at the onset of mitosis and rebinds at telophase when the pre-replication complexes (pre-RC) is formed (PubMed:25990725) |
| Tissue Location | Widely expressed.. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
GRWD1 is a component of the 50S and 80S preribosomal complexes and plays a role in ribosome biogenesis (Gratenstein et al., 2005 [PubMed 15885502]).
REFERENCES
Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)
Gratenstein, K., et al. Genomics 85(6):762-773(2005)
Trzcinska, A.M., et al. Mol. Biol. Rep. 29(4):347-352(2002)
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¥ 1,250.00
Cat# AP18456c
