癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAB40C Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96S21 |
| Other Accession | Q8VHQ4, NP_001166134.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31304 Da |
| Antigen Region | 122-148 aa |
| Gene ID | 57799 |
|---|---|
| Other Names | Ras-related protein Rab-40C, Rar-like protein, Ras-like protein family member 8C, SOCS box-containing protein RAR3, RAB40C, RARL, RASL8C |
| Target/Specificity | This RAB40C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-148 amino acids from the Central region of human RAB40C. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAB40C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RAB40C (HGNC:18285) |
|---|---|
| Synonyms | RARL, RASL8C |
| Function | RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytosol. Golgi apparatus membrane. Note=Mostly localized in the cytosol and also with actin ruffles. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
REFERENCES
Ng, E.L., et al. Brain Res Rev 58(1):236-246(2008)
Lettre, G., et al. Nat. Genet. 40(5):584-591(2008)
Martin, J., et al. Nature 432(7020):988-994(2004)
Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
Pereira-Leal, J.B., et al. J. Mol. Biol. 313(4):889-901(2001)
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