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为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
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HORMAD1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q86X24 |
| Other Accession | D3ZWE7, E2IUK4, Q9D5T7, Q4R8B9, Q2KIY6, NP_115508.2 |
| Reactivity | Human |
| Predicted | Bovine, Monkey, Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45200 Da |
| Antigen Region | 161-189 aa |
| Gene ID | 84072 |
|---|---|
| Other Names | HORMA domain-containing protein 1, Cancer/testis antigen 46, CT46, Newborn ovary HORMA protein, HORMAD1, NOHMA |
| Target/Specificity | This HORMAD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the Central region of human HORMAD1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HORMAD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HORMAD1 (HGNC:25245) |
|---|---|
| Function | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single- stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9D5T7}. Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser- 377 is restricted to unsynapsed chromosomal regions (By similarity) {ECO:0000250|UniProtKB:Q9D5T7} |
| Tissue Location | Testis-specific. Over-expressed in carcinomas. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
HORMAD1 may monitor and regulate pairing, synapsis, or recombination between homologous chromosomes during meiosis (By similarity).
REFERENCES
Chen, Y.T., et al. Cancer Immun. 5, 9 (2005) :
Pangas, S.A., et al. Gene Expr. Patterns 5(2):257-263(2004)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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Discontinued
Cat# AP18581c
Size:
50 µl
100 µl
200 µl
400 µl
Price:
¥ 1,250.00
¥ 2,050.00
¥ 2,960.00
¥ 4,550.00
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