癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RAB22A Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UL26 |
| Other Accession | P35285, NP_065724.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21855 Da |
| Antigen Region | 166-192 aa |
| Gene ID | 57403 |
|---|---|
| Other Names | Ras-related protein Rab-22A, Rab-22, RAB22A, RAB22 |
| Target/Specificity | This RAB22A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-192 amino acids from the C-terminal region of human RAB22A. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAB22A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB22A |
|---|---|
| Synonyms | RAB22 |
| Function | Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor. Cell membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor. Early endosome. Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.
REFERENCES
Zhu, H., et al. Mol. Biol. Cell 20(22):4720-4729(2009)
Magadan, J.G., et al. Mol. Cell. Biol. 26(7):2595-2614(2006)
Mesa, R., et al. Exp. Cell Res. 304(2):339-353(2005)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Weigert, R., et al. Mol. Biol. Cell 15(8):3758-3770(2004)
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