癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
APBA3 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | O96018 |
| Other Accession | NP_004877.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61454 Da |
| Antigen Region | 299-327 aa |
| Gene ID | 9546 |
|---|---|
| Other Names | Amyloid beta A4 precursor protein-binding family A member 3, Adapter protein X11gamma, Neuron-specific X11L2 protein, Neuronal Munc18-1-interacting protein 3, Mint-3, APBA3, MINT3, X11L2 |
| Target/Specificity | This APBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the Central region of human APBA3. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | APBA3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | APBA3 |
|---|---|
| Synonyms | MINT3, X11L2 |
| Function | May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN. |
| Cellular Location | Cytoplasm, perinuclear region |
| Tissue Location | Expressed in all tissues examined with lower levels in brain and testis |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease.
REFERENCES
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010) Swistowski, A., et al. J. Neurosci. 29(50):15703-15712(2009) Sakamoto, T., et al. J. Biol. Chem. 284(44):30350-30359(2009) Han, J., et al. J. Cell. Sci. 121 (PT 13), 2217-2223 (2008) : Shrivastava-Ranjan, P., et al. Mol. Biol. Cell 19(1):51-64(2008)
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