癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PASD1 Antibody (Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IV76 |
| Other Accession | NP_775764.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 87428 Da |
| Antigen Region | 283-310 aa |
| Gene ID | 139135 |
|---|---|
| Other Names | PAS domain-containing protein 1, Cancer/testis antigen 63, CT63, OX-TES-1, PASD1 |
| Target/Specificity | This PASD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 283-310 amino acids from the Central region of human PASD1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PASD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PASD1 (HGNC:20686) |
|---|---|
| Function | Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). |
| Cellular Location | [Isoform 1]: Nucleus. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801) |
| Tissue Location | Testis-specific (PubMed:25936801). Expressed in a broad range of cancer cells, including melanoma, lung cancer, and breast cancer (at protein level). Testis-specific (PubMed:15162151) Found in histologically normal tissues from patients with uterus, lung and small intestine cancers. Widespread expression seen in solid tumors and diffuse large B-cell lymphoma (DLBCL)-derived cell lines. Isoform 2 is expressed in all DLBCL-derived cell lines, while isoform 1 is preferentially expressed in cell lines derived from non-germinal center DLBCL (PubMed:15162151). |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma.
REFERENCES
Ghafouri-Fard, S., et al. Br. J. Dermatol. 162(4):772-779(2010)
Ait-Tahar, K., et al. Br. J. Haematol. 146(4):396-407(2009)
Sahota, S.S., et al. Blood 108(12):3953-3955(2006)
Cooper, C.D., et al. Leukemia 20(12):2172-2174(2006)
Guinn, B.A., et al. Biochem. Biophys. Res. Commun. 335(4):1293-1304(2005)
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