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LGI3 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N145 |
| Other Accession | Q8K406, Q4R4H3, NP_644807.1 |
| Reactivity | Human |
| Predicted | Monkey, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61704 Da |
| Antigen Region | 310-338 aa |
| Gene ID | 203190 |
|---|---|
| Other Names | Leucine-rich repeat LGI family member 3, LGI1-like protein 4, Leucine-rich glioma-inactivated protein 3, LGI3, LGIL4 |
| Target/Specificity | This LGI3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-338 amino acids from the Central region of human LGI3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LGI3 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LGI3 |
|---|---|
| Synonyms | LGIL4 |
| Function | May participate in the regulation of neuronal exocytosis. |
| Cellular Location | Secreted. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q8K406}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q8K406}. Cell projection, axon {ECO:0000250|UniProtKB:Q8K406}. Note=Found in the synaptosomal membrane fraction. Within peripheral myelinated axons, LGI3 is highly expressed at the juxtaparanodal membrane and colocalizes with the voltage-gated potassium channels Kv1.1 (KCNA1) and Kv1.2 (KCNA2), and with CNTNAP2, DLG4, ADAM22 and ADAM23 (By similarity) {ECO:0000250|UniProtKB:Q8K406} |
| Tissue Location | Widely expressed, with highest levels in brain and lung. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
LGI3 may participate in the regulation of neuronal exocytosis (By similarity).
REFERENCES
Okabayashi, S., et al. Neuroreport 19(12):1175-1179(2008)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Staub, E., et al. Trends Biochem. Sci. 27(9):441-444(2002)
Scheel, H., et al. Hum. Mol. Genet. 11(15):1757-1762(2002)
Gu, W., et al. FEBS Lett. 519 (1-3), 71-76 (2002) :
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