癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PDE6H Antibody(Center) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q13956 |
| Other Accession | P09174, P18545, P04972, P61250, P61249, P22571, NP_006196.1 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Rat, Human, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 9074 Da |
| Antigen Region | 4-33 aa |
| Gene ID | 5149 |
|---|---|
| Other Names | Retinal cone rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma, PDE6H |
| Target/Specificity | This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDE6H Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PDE6H (HGNC:8790) |
|---|---|
| Function | Inhibitory gamma subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity). The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H) (By similarity). Light-activated GNAT2 relieves gamma subunit-mediated inhibition, allowing the catalytic subunits to hydrolyze cGMP and mediate visual signal transduction and amplification. The resulting decrease in cytosolic cGMP levels triggers the closure of cGMP-gated cation channels at the plasma membrane, leading to hyperpolarization of cone photoreceptors (By similarity). Inhibition by the gamma subunit is relatively dynamic and less tightly coupled than in rods, allowing transient access to the catalytic pocket and facilitating the rapid phototransduction kinetics characteristic of cones (By similarity). |
| Cellular Location | Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P61249}. Note=Localized in cone outer segment disk membranes. {ECO:0000250|UniProtKB:P61249} |
| Tissue Location | Expressed in the retina, specifically in cone photoreceptors. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Piri, N., et al. Ophthalmology 112(1):159-166(2005)
Kajimura, N., et al. J. Struct. Biol. 139(1):27-38(2002)
Shimizu-Matsumoto, A., et al. Genomics 32(1):121-124(1996)
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