癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RBMY1A1 Antibody(C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P0DJD3 |
| Other Accession | Q15415, A6NEQ0, P0C7P1, P0DJD4, A6NDE4, Q15414, NP_005049.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55784 Da |
| Antigen Region | 468-496 aa |
| Gene ID | 5940 |
|---|---|
| Other Names | RNA-binding motif protein, Y chromosome, family 1 member A1, RNA-binding motif protein 1, RNA-binding motif protein 2, Y chromosome RNA recognition motif 1, hRBMY, RBMY1A1, RBM1, RBM2, YRRM1, YRRM2 |
| Target/Specificity | This RBMY1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 468-496 amino acids from the C-terminal region of human RBMY1A1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RBMY1A1 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RBMY1A1 |
|---|---|
| Synonyms | RBM1, RBM2, YRRM1, YRRM2 |
| Function | RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs. |
| Cellular Location | Nucleus. |
| Tissue Location | Testis-specific.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq].
REFERENCES
Dreumont, N., et al. J. Cell. Sci. 123 (PT 1), 40-50 (2010) :
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :
Lardone, M.C., et al. Mol. Hum. Reprod. 13(10):705-712(2007)
Skrisovska, L., et al. EMBO Rep. 8(4):372-379(2007)
Lavery, R., et al. Arch. Androl. 53(2):71-73(2007)
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