癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TES Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UGI8 |
| Other Accession | Q2QLE3, Q90YH9, Q2YDE9, NP_690042.1 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 47996 Da |
| Antigen Region | 41-70 aa |
| Gene ID | 26136 |
|---|---|
| Other Names | Testin, TESS, TES |
| Target/Specificity | This TES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human TES. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TES Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TES |
|---|---|
| Function | Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth. |
| Cellular Location | Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers |
| Tissue Location | Ubiquitous.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.
REFERENCES
Qiu, H., et al. Cancer Sci. 101(5):1255-1260(2010)
Gunduz, E., et al. Arch. Otolaryngol. Head Neck Surg. 135(3):254-260(2009)
Zhong, Y., et al. Mol. Cell. Biochem. 320 (1-2), 85-92 (2009) :
Huang, W., et al. Ai Zheng 27(9):984-988(2008)
Boeda, B., et al. Mol. Cell 28(6):1071-1082(2007)
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