癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TES Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TES.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q9UGI8 |
| Other Accession | BC001451 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1G11-B7 |
| Calculated MW | 47996 Da |
| Gene ID | 26136 |
|---|---|
| Other Names | Testin, TESS, TES |
| Target/Specificity | TES (AAH01451, 1 a.a. ~ 421 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TES Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.
REFERENCES
Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer. Qiu H, et al. Cancer Sci, 2010 May. PMID 20180808.Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma. Gunduz E, et al. Arch Otolaryngol Head Neck Surg, 2009 Mar. PMID 19289703.[Expression and clinical significance of TESTIN in primary gastric cancer] Huang W, et al. Ai Zheng, 2008 Sep. PMID 18799041.LIM domain protein TES changes its conformational states in different cellular compartments. Zhong Y, et al. Mol Cell Biochem, 2009 Jan. PMID 18696217.Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Bo?da B, et al. Mol Cell, 2007 Dec 28. PMID 18158903.
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