癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ATOH7 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8N100 |
| Other Accession | NP_660161.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 16871 Da |
| Antigen Region | 85-112 aa |
| Gene ID | 220202 |
|---|---|
| Other Names | Protein atonal homolog 7, Class A basic helix-loop-helix protein 13, bHLHa13, Helix-loop-helix protein hATH-5, hATH5, ATOH7, ATH5, BHLHA13 |
| Target/Specificity | This ATOH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the Central region of human ATOH7. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ATOH7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ATOH7 (HGNC:13907) |
|---|---|
| Synonyms | ATH5, BHLHA13 |
| Function | Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' (PubMed:31696227). Dimerization with TCF3 isoform E47 may be required in certain situations (PubMed:31696227). Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (By similarity). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (By similarity). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). |
| Cellular Location | Nucleus. Perikaryon {ECO:0000250|UniProtKB:Q9Z2E5}. Cell projection, axon {ECO:0000250|UniProtKB:Q9Z2E5} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ATOH7 is a member of the family of basic helix-loop-helix (bHLH) proteins with similarity to Drosophila 'atonal,' a proneural bHLH gene that controls photoreceptor development (Brown et al., 2002 [PubMed 11889557]).
REFERENCES
Macgregor, S., et al. Hum. Mol. Genet. 19(13):2716-2724(2010)
Ramdas, W.D., et al. PLoS Genet. 6 (6), E1000978 (2010) :
McLellan, A.S., et al. Mech. Dev. 119 SUPPL 1, S285-S291 (2002) :
McLellan, A.S., et al. Gene Expr. Patterns 2 (3-4), 329-335 (2002) :
Brown, N.L., et al. Mamm. Genome 13(2):95-101(2002)
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