癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FUNDC2 Antibody (C-term) 精选
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BWH2 |
| Other Accession | Q864V5, Q9D6K8, Q8MJN0, NP_076423.2 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine, Pig, Canine, Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20676 Da |
| Antigen Region | 122-150 aa |
| Gene ID | 65991 |
|---|---|
| Other Names | FUN14 domain-containing protein 2, Cervical cancer proto-oncogene 3 protein, HCC-3, Hepatitis C virus core-binding protein 6, FUNDC2, HCBP6 |
| Target/Specificity | This FUNDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the C-terminal region of human FUNDC2. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FUNDC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FUNDC2 (HGNC:24925) |
|---|---|
| Synonyms | HCBP6 |
| Function | Binds directly and specifically 1,2-Diacyl-sn-glycero-3- phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein. Nucleus |
| Tissue Location | Highly expressed in platelets (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The function of this protein is unknown.
REFERENCES
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Li, K., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16(4):351-353(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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Cat# AP20155b
