癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
FUNDC2 Rabbit pAb
- 产品详情
- 实验流程
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9BWH2 |
| Other Accession | Q9BWH2 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20676 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human FUNDC2 |
| Epitope Specificity | 101-189/189 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the FUN14 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | FUNDC2 is a 189 amino acid protein belonging to the FUN14 family. The gene encoding FUNDC2 maps to human chromosome Xq28. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. |
| Gene ID | 65991 |
|---|---|
| Other Names | DC44; HCBP6; HCC3; PD03104; 4833415N24Rik; FUND2_HUMAN; FUNDC2; Cervical cancer proto-oncogene 3 protein (HCC-3); Hepatitis C virus core-binding protein 6; FUND2_MOUSE; FUN14 domain containing 2 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | FUNDC2 (HGNC:24925) |
|---|---|
| Synonyms | HCBP6 |
| Function | Binds directly and specifically 1,2-Diacyl-sn-glycero-3- phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein. Nucleus |
| Tissue Location | Highly expressed in platelets (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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