癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MAP2 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P11137 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 199526 Da |
| Antigen Region | 1766-1796 aa |
| Gene ID | 4133 |
|---|---|
| Other Names | Microtubule-associated protein 2, MAP-2, MAP2 |
| Target/Specificity | This MAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1766-1796 amino acids from the C-terminal region of human MAP2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MAP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP2 |
|---|---|
| Function | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell projection, dendrite {ECO:0000250|UniProtKB:P20357} |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The exact function of this gene is still unknown. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development.
REFERENCES
Lauckner, J., et al., Neurobiol. Aging 24(6):767-776 (2003).
Laurine, E., et al., J. Biol. Chem. 278(32):29979-29986 (2003).
Liu, Y., et al., Adv Anat Pathol 10(2):101-106 (2003).
DeTure, M.A., et al., J. Biol. Chem. 277(38):34755-34759 (2002).
Al-Bassam, J., et al., J. Cell Biol. 157(7):1187-1196 (2002).
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