癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
POLR2H Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P52434 |
| Other Accession | Q923G2, NP_006223.2 |
| Reactivity | Human, Mouse |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 17143 Da |
| Antigen Region | 59-87 aa |
| Gene ID | 5437 |
|---|---|
| Other Names | DNA-directed RNA polymerases I, II, and III subunit RPABC3, RNA polymerases I, II, and III subunit ABC3, DNA-directed RNA polymerase II subunit H, DNA-directed RNA polymerases I, II, and III 171 kDa polypeptide, RPB17, RPB8 homolog, hRPB8, POLR2H |
| Target/Specificity | This POLR2H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-87 amino acids from the Central region of human POLR2H. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | POLR2H Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | POLR2H (HGNC:9195) |
|---|---|
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. |
| Cellular Location | Nucleus {ECO:0000269|PubMed:33335104, ECO:0000269|PubMed:9852112, ECO:0000269|Ref.6}. Nucleus, nucleolus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.
REFERENCES
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Kang, X., et al. J. Biol. Chem. 281(26):18216-18226(2006)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
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