癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SFXN1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9H9B4 |
| Other Accession | NP_073591.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35619 Da |
| Antigen Region | 293-321 aa |
| Gene ID | 94081 |
|---|---|
| Other Names | Sideroflexin-1, Tricarboxylate carrier protein, TCC, SFXN1 |
| Target/Specificity | This SFXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human SFXN1. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SFXN1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SFXN1 (HGNC:16085) |
|---|---|
| Function | Amino acid transporter importing serine, an essential substrate of the mitochondrial branch of the one-carbon pathway, into mitochondria. Mitochondrial serine is then converted to glycine and formate, which exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (PubMed:30442778). May also transport other amino acids including alanine and cysteine (PubMed:30442778). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Highly expressed in tissues with high one-carbon metabolism activity, such as blood, liver and kidney |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Might be involved in the transport of a component required for iron utilization into or out of the mitochondria.
REFERENCES
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Siculella, L., et al. FEBS Lett. 578(3):280-284(2004)
Siculella, L., et al. J. Lipid Res. 45(7):1333-1340(2004)
Giudetti, A.M., et al. J. Lipid Res. 44(11):2135-2141(2003)
Miyake, S., et al. Biochem. Biophys. Res. Commun. 295(2):463-468(2002)
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