癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Mouse Ptk7 Antibody (C-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8BKG3 |
| Reactivity | Human, Mouse |
| Predicted | Rat, Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 117532 Da |
| Gene ID | 71461 |
|---|---|
| Other Names | Inactive tyrosine-protein kinase 7, Protein chuzhoi, Protein-tyrosine kinase 7, Pseudo tyrosine kinase receptor 7, Tyrosine-protein kinase-like 7, Ptk7 |
| Target/Specificity | This mouse Ptk7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 722-757 amino acids from the C-terminal region of mouse Ptk7. |
| Dilution | WB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Ptk7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Ptk7 |
|---|---|
| Function | Inactive tyrosine kinase involved in the Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathways. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Does not bind ATP (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q13308}; Single-pass type I membrane protein. Cell junction {ECO:0000250|UniProtKB:Q13308}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells {ECO:0000250|UniProtKB:Q13308} |
| Tissue Location | Expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
REFERENCES
Jung J.-W.,et al.Gene 328:75-84(2004).
Carninci P.,et al.Science 309:1559-1563(2005).
Daigo Y.,et al.Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
Lu X.,et al.Nature 430:93-98(2004).
Gundry R.L.,et al.Mol. Cell. Proteomics 8:2555-2569(2009).
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