癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RABEP1 Antibody (Center) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q15276 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Bovine, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 99290 Da |
| Gene ID | 9135 |
|---|---|
| Other Names | Rab GTPase-binding effector protein 1, Rabaptin-4, Rabaptin-5, Rabaptin-5alpha, Renal carcinoma antigen NY-REN-17, RABEP1, RAB5EP, RABPT5, RABPT5A |
| Target/Specificity | This RABEP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 427-461 amino acids from the Central region of human RABEP1. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RABEP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | RABEP1 (HGNC:17677) |
|---|---|
| Function | Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Forms a complex with RABGEF1 that stimulates RABGEF1-mediated nucleotide exchange on RAB5A (PubMed:9323142). Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). |
| Cellular Location | Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.
REFERENCES
Stenmark H.,et al.Cell 83:423-432(1995).
Nagelkerken B.,et al.Biochem. J. 346:593-601(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Horiuchi H.,et al.Cell 90:1149-1159(1997).
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