癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SAPCD2 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q86UD0 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42637 Da |
| Gene ID | 89958 |
|---|---|
| Other Names | Suppressor APC domain-containing protein 2, Tumor specificity and mitosis phase-dependent expression protein, TS/MDEP, p42.3, SAPCD2, C9orf140 |
| Target/Specificity | This SAPCD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 333-367 amino acids from human SAPCD2. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SAPCD2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SAPCD2 (HGNC:28055) |
|---|---|
| Synonyms | C9orf140 |
| Function | Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By similarity). Negatively regulates the mitotic apical cortex localization of GPSM2 (PubMed:26766442). Involved also in positive regulation of cell proliferation and tumor cell growth (PubMed:23576022, PubMed:23704824). |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, cell cortex. Apical cell membrane {ECO:0000250|UniProtKB:Q9D818}. Cell junction, tight junction. Note=Localized at the apical cortical region during the M phase. In horizontally retinal progenitor dividing cells, localized at the pole cortical region from prophase to telophase cells. In vertically retinal progenitor dividing cells, not detected at the pole cortical region at any stage of mitosis {ECO:0000250|UniProtKB:Q9D818} |
| Tissue Location | Expressed in 5-month-old fetal tissues, including stomach, intestine, colon, liver, brain, lung, heart, spleen and kidney (PubMed:17525738). Undetectable in non-cancerous adult tissues (PubMed:17525738). Expressed in many primary gastric carcinoma, but almost not in adjacent normal mucosa (PubMed:17525738). Expressed preferentially in M and G1 phases, compared to S and G2 phases (PubMed:17525738). Expression is up-regulated in hepatocellular carcinoma (HCC) and colorectal cancer (CRC) tissues (at protein level) (PubMed:23704824). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Xu X.,et al.Oncogene 26:7371-7379(2007).
Humphray S.J.,et al.Nature 429:369-374(2004).
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¥ 1,250.00
Cat# AP21936b
