癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
PPAPDC1B Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q8NEB5 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29484 Da |
| Gene ID | 84513 |
|---|---|
| Other Names | Phosphatidate phosphatase PPAPDC1B, 3.1.3.4, Phosphatidic acid phosphatase type 2 domain-containing protein 1B, PPAPDC1B, DPPL1, HTPAP |
| Target/Specificity | This PPAPDC1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 114-146 amino acids from the Central region of human PPAPDC1B. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPAPDC1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLPP5 (HGNC:25026) |
|---|---|
| Function | Magnesium-independent phospholipid phosphatase with broad substrate specificity (PubMed:17590538). Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate (PubMed:17590538). Phospholipid phosphatases are involved in both the synthesis of lipids and the generation or degradation of lipid-signaling molecules (PubMed:17590538). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q3UMZ3} |
| Tissue Location | Ubiquitous.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
REFERENCES
Takeuchi M.,et al.Gene 399:174-180(2007).
Nusbaum C.,et al.Nature 439:331-335(2006).
Li Y.,et al.Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
Wu X.,et al.Oncogene 25:1832-1840(2006).
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