癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ANKRD1 Antibody (N-Term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q15327 |
| Other Accession | Q3ZBX7, Q865U8 |
| Reactivity | Human |
| Predicted | Bovine, Pig, Canine, Rabbit, Chicken |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36252 Da |
| Gene ID | 27063 |
|---|---|
| Other Names | Ankyrin repeat domain-containing protein 1, Cardiac ankyrin repeat protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein, ANKRD1, C193, CARP, HA1A2 |
| Target/Specificity | This ANKRD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-34 amino acids from human ANKRD1. |
| Dilution | WB~~1:2000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ANKRD1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ANKRD1 |
|---|---|
| Synonyms | C193, CARP, HA1A2 |
| Function | May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. |
| Cellular Location | Nucleus |
| Tissue Location | Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
REFERENCES
Chu W.,et al.J. Biol. Chem. 270:10236-10245(1995).
Park J.-H.,et al.Cancer Res. 65:2804-2814(2005).
Deloukas P.,et al.Nature 429:375-381(2004).
Miller M.K.,et al.J. Mol. Biol. 333:951-964(2003).
Cinquetti R.,et al.Hum. Mutat. 29:468-474(2008).
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