癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ADCY2 Antibody (C-term) 精选
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q08462 |
| Reactivity | Human |
| Predicted | Mouse, Rat, Rabbit, Chicken, Bovine, Canine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 123603 Da |
| Antigen Region | 940-969 aa |
| Gene ID | 108 |
|---|---|
| Other Names | Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, ADCY2, KIAA1060 |
| Target/Specificity | This ADCY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-969 amino acids from the C-terminal region of human ADCY2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ADCY2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADCY2 |
|---|---|
| Synonyms | KIAA1060 |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). |
| Cellular Location | Membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm |
| Tissue Location | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ADCY2 is a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate(cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
REFERENCES
Uhl,G.R.,Arch. Gen. Psychiatry 65 (6), 683-693 (2008)
Ludwig,M.G.,J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002)
Cote,M., J. Clin. Endocrinol. Metab. 86 (9), 4495-4503 (2001)
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