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CAPZB Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P47756 |
| Other Accession | Q5XI32, A0PFK7, P47757, P14315, P79136 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse, Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 30629 Da |
| Antigen Region | 54-81 aa |
| Gene ID | 832 |
|---|---|
| Other Names | F-actin-capping protein subunit beta, CapZ beta, CAPZB |
| Target/Specificity | This CAPZB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human CAPZB. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CAPZB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CAPZB (HGNC:1491) |
|---|---|
| Function | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A9XFX6}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:A9XFX6} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CAPZB is a member of the F-actin capping protein family. This protein is the beta subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments.
REFERENCES
Wells,C.D., Cell 125 (3), 535-548 (2006) Bruneel,A., Proteomics 5 (15), 3876-3884 (2005)
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