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>   首页   >   产品   >   一抗   >   精选抗体   >   磷酸化抗体   >   Phospho-p16-INK4A(S140) Antibody   

Phospho-p16-INK4A(S140) Antibody

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - Phospho-p16-INK4A(S140) Antibody AP3183a
    The anti-Phospho-p16-INK4A-S140 Pab (Cat. #AP3183a) is used in Western blot to detect Phospho-p16-INK4A-S140 in A2058 tissue lysate
  • 14 - Phospho-p16-INK4A(S140) Antibody AP3183a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, E
Primary Accession P42771
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 16533 Da
Additional Information
Gene ID 1029
Other Names Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3, Cyclin-dependent kinase 4 inhibitor A, CDK4I, Multiple tumor suppressor 1, MTS-1, p16-INK4a, p16-INK4, p16INK4A, CDKN2A, CDKN2, MTS1
Target/Specificity This p16-INK4A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S140 of human p16-INK4A.
Dilution WB~~1:1000
IHC-P~~1:100~500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-p16-INK4A(S140) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDKN2A (HGNC:1787)
Synonyms CDKN2, MTS1
Function Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific
Research Areas

BACKGROUND

p16-INK4A functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. This protein acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The gene for this protein is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

REFERENCES

Ausserlechner, M.J., et al., Leukemia 19(6):1051-1057 (2005).
Kawamata, N., et al., Eur. J. Haematol. 74(5):424-429 (2005).
Wang, J.L., et al., Mod. Pathol. 18(5):629-637 (2005).
Kuroda, H., et al., Cancer Genet. Cytogenet. 158(2):172-179 (2005).
Fu, G.H., et al., FEBS Lett. 579(10):2105-2110 (2005).

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