Phospho-CRK(S41) Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| DB, E |
---|---|
Primary Accession | P46108 |
Other Accession | Q63768, Q64010, Q96GA9 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 33831 Da |
Gene ID | 1398 |
---|---|
Other Names | Adapter molecule crk, Proto-oncogene c-Crk, p38, CRK |
Target/Specificity | This CRK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S41 of human CRK. |
Dilution | DB~~1:500 E~~Use at an assay dependent concentration. |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Phospho-CRK(S41) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CRK |
---|---|
Function | Involved in cell branching and adhesion mediated by BCAR1- CRK-RAPGEF1 signaling and activation of RAP1. |
Cellular Location | Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CRK is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.
REFERENCES
Bougneres, L., et al., J. Cell Biol. 166(2):225-235 (2004).
Stoletov, K.V., et al., Exp. Cell Res. 295(1):258-268 (2004).
Miller, C.T., et al., Oncogene 22(39):7950-7957 (2003).
Sun, J., et al., J. Biol. Chem. 278(35):32794-32800 (2003).
Zhang, X.A., et al., J. Biol. Chem. 278(29):27319-27328 (2003).

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