癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CrkII Antibody
Purified Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P46108 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Calculated MW | 33831 Da |
| Gene ID | 1398 |
|---|---|
| Other Names | Adapter molecule crk;Avian sarcoma virus CT10 (v crk) oncogene homolog;CRK;CRK isoform 2;CRK isoform II;CRK_HUMAN;CRKII;FLJ38130;OTTHUMP00000115366;OTTHUMP00000198330;p38; Proto oncogene C crk;Proto-oncogene C-crk;v crk avian sarcoma virus CT10 oncogene homolog;v crk sarcoma virus CT10 oncogene homolog;v crk sarcoma virus CT10 oncogene homolog (avian). |
| Dilution | WB~~1:1000 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CRK |
|---|---|
| Function | Involved in cell branching and adhesion mediated by BCAR1- CRK-RAPGEF1 signaling and activation of RAP1. |
| Cellular Location | Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
REFERENCES
Matsuda M.,et al.Mol. Cell. Biol. 12:3482-3489(1992).
Fioretos T.,et al.Oncogene 8:2853-2855(1993).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
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