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CDCA2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - CDCA2 Antibody AP50761
    Western blot analysis of lysates from Hela,A431 cell line (from left to right),using CDCA2 Antibody(AP50761). AP50761 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q69YH5
Reactivity Human
Host Rabbit
Clonality polyclonal
Calculated MW 113 KDa
Additional Information
Other Names Cell division cycle-associated protein 2, Recruits PP1 onto mitotic chromatin at anaphase protein, Repo-Man, CDCA2
Dilution WB~~ 1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol.
Storage Conditions-20℃

For Research Use Only. Not For Use In Diagnostic Procedures.

Protein Information
Research Areas

BACKGROUND

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

REFERENCES

Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Nusbaum C.,et al.Nature 439:331-335(2006).
Walker M.G.,et al.Curr. Cancer Drug Targets 1:73-83(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Olsen J.V.,et al.Cell 127:635-648(2006).

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