癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MOG Rabbit pAb
MOG Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q61885 |
| Reactivity | Rat, Mouse |
| Predicted | Pig, Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 28271 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from mouse MOG |
| Epitope Specificity | 35-55/247 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein (Potential). |
| DISEASE | Defects in MOG are the cause of narcolepsy type 7 (NRCLP7) [MIM:614250]. Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| Gene ID | 17441 |
|---|---|
| Other Names | Myelin-oligodendrocyte glycoprotein, Mog |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Mog |
|---|---|
| Function | Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes Reduced expression levels are observed in jimpy and quacking dysmyelinating mutant mice. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
REFERENCES
Hilton A.A.,et al.J. Neurochem. 65:309-318(1995).
Pham-Dinh D.,et al.J. Neurochem. 63:2353-2356(1994).
Roth M.-P.,et al.Genomics 28:241-250(1995).
Pham-Dinh D.,et al.Genomics 29:345-352(1995).
Ballenthin P.A.,et al.J. Neurosci. Res. 46:271-281(1996).
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