ERAP1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application ![]()
| WB |
---|---|
Primary Accession | Q9NZ08 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 107235 Da |
Gene ID | 51752 |
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Other Names | Endoplasmic reticulum aminopeptidase 1, 3411-, ARTS-1, Adipocyte-derived leucine aminopeptidase, A-LAP, Aminopeptidase PILS, Puromycin-insensitive leucyl-specific aminopeptidase, PILS-AP, Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator, ERAP1, APPILS, ARTS1, KIAA0525 |
Target/Specificity | KLH conjugated synthetic peptide derived from human ERAP1 |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | ERAP1 |
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Synonyms | APPILS, ARTS1, KIAA0525 |
Function | Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
Tissue Location | Ubiquitous. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
REFERENCES
Hattori A.,et al.J. Biochem. 125:931-938(1999).
Hattori A.,et al.J. Biochem. 130:235-241(2001).
Schomburg L.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Cui X.,et al.Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 5:31-39(1998).

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