癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Septin 7 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB |
|---|---|
| Primary Accession | Q16181 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50680 Da |
| Gene ID | 989 |
|---|---|
| Other Names | Septin-7, CDC10 protein homolog, SEPT7, CDC10 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human Septin 7 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SEPTIN7 (HGNC:1717) |
|---|---|
| Synonyms | CDC10, SEPT7 |
| Function | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). |
| Cellular Location | Cytoplasm. Chromosome, centromere, kinetochore Cytoplasm, cytoskeleton, spindle Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase Associated with actin stress fibers (By similarity). Found in the sperm annulus (PubMed:25588830). {ECO:0000250, ECO:0000269|PubMed:25588830} |
| Tissue Location | Widely expressed.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements.
REFERENCES
Nakatsuru S.,et al.Biochem. Biophys. Res. Commun. 202:82-87(1994).
Nagata K.,et al.J. Biol. Chem. 279:55895-55904(2004).
Hall P.A.,et al.J. Pathol. 206:269-278(2005).
Kremer B.E.,et al.Mol. Biol. Cell 16:4648-4659(2005).
Rush J.,et al.Nat. Biotechnol. 23:94-101(2005).
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