Topoisomerase 2 alpha Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- 实验流程
- 背景知识
Application ![]()
| WB |
---|---|
Primary Accession | P11388 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 174385 Da |
Gene ID | 7153 |
---|---|
Other Names | DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2 |
Target/Specificity | KLH conjugated synthetic peptide derived from human Topoisomerase 2 alpha |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | TOP2A |
---|---|
Synonyms | TOP2 |
Function | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity). |
Cellular Location | Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus |
Tissue Location | Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.
REFERENCES
Tsai-Pflugfelder M.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7177-7181(1988).
Wasserman R.A.,et al.Cancer Res. 53:3591-3596(1993).
Lang A.J.,et al.Gene 221:255-266(1998).
Sng J.H.,et al.Biochim. Biophys. Acta 1444:395-406(1999).
Zody M.C.,et al.Nature 440:1045-1049(2006).

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