Kalirin Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, ICC |
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Primary Accession | O60229 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 340261 Da |
Gene ID | 8997 |
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Other Names | Kalirin, Huntingtin-associated protein-interacting protein, Protein Duo, Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain, KALRN, DUET, DUO, HAPIP, TRAD |
Dilution | WB~~1:1000 ICC~~N/A |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | KALRN (HGNC:4814) |
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Synonyms | DUET, DUO, HAPIP, TRAD |
Function | Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with the cytoskeleton |
Tissue Location | Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.
REFERENCES
Colomer V.,et al.Hum. Mol. Genet. 6:1519-1525(1997).
Kawai T.,et al.Gene 227:249-255(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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