癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-TAB1 Antibody
Mouse Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
| Primary Accession | Q15750 |
|---|---|
| Other Accession | NM_006116 |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | lgG2b |
| Immunogen | Purified recombinant human TAB1 protein expressed in E.coli. |
| Purification | Affinity purified |
| Calculated MW | 54644 Da |
| Gene ID | 10454 |
|---|---|
| Other Names | 2310012M03Rik;3'-Tab1;MAP3K7IP1;MAP3K7IP1;MGC57664;Mitogenactivatedproteinkinasekinasekinase7interactingprotein1;Mitogen-activatedproteinkinasekinasekinase7-interactingprotein1;TAB1;TAB1;TAB1_HUMAN;TAK1bindingprotein1;TAK1-bindingprotein1;TGFbetaactivatedkinase1bindingprotein1;TGF-betaactivatedkinase1/MAP3K7bindingprotein1;TGF-beta-activatedkinase1andMAP3K7-bindingprotein1;TGF-beta-activatedkinase1-bindingprotein1;Transforminggrowthfactorbetaactivatedkinasebindingprotein1. |
| Format | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | TAB1 |
|---|---|
| Synonyms | MAP3K7IP1 |
| Function | Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530). Mechanistically, associates with the catalytic domain of MAP3K7/TAK1 to trigger MAP3K7/TAK1 autophosphorylation leading to its full activation (PubMed:10838074, PubMed:25260751, PubMed:37832545). Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647). In turn, MAPK14 phosphorylates TAB1 and inhibits MAP3K7/TAK1 activation in a feedback control mechanism (PubMed:14592977). Also plays a role in recruiting MAPK14 to the TAK1 complex for the phosphorylation of the TAB2 and TAB3 regulatory subunits (PubMed:18021073). |
| Cellular Location | Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the endoplasmic reticulum following interaction with STING1 |
| Tissue Location | Ubiquitous.. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
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Discontinued
Cat# AP53465
Size:
50 µl
100 µl
Price:
¥ 1,500.00
¥ 2,600.00
替代产品:
