癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KBTBD8 Mouse mAb
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, FC |
|---|---|
| Primary Accession | Q8NFY9 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal Antibody |
| Isotype | IgG1 |
| Conjugate | Unconjugated |
| Immunogen | Purified recombinant fragment of human KBTBD8 expressed in E. Coli. |
| Purification | Affinity Purified |
| Calculated MW | 68823 Da |
| Gene ID | 84541 |
|---|---|
| Other Names | TA-KRP |
| Dilution | WB~~1:1000 FC~~1:10~50 |
| Format | Liquid in Purified antibody in PBS with 0.05% sodium azide. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KBTBD8 |
|---|---|
| Synonyms | KIAA1842, TAKRP |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). |
| Cellular Location | Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Translocates to the spindle apparatus during mitosis. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Swiss-Prot Acc.Q8NFY9.KBTBD8 (kelch repeat and BTB (POZ) domain containing 8) is a protein-coding gene. An important paralog of this gene is KLHL21.
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