癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AXIN2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q9Y2T1 |
| Other Accession | O70240, O88566, NP_004646.3 |
| Reactivity | Human, Rat, Mouse |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 93568 Da |
| Antigen Region | 816-843 aa |
| Gene ID | 8313 |
|---|---|
| Other Names | Axin-2, Axin-like protein, Axil, Axis inhibition protein 2, Conductin, AXIN2 |
| Target/Specificity | This AXIN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-843 amino acids from the C-terminal region of human AXIN2. |
| Dilution | WB~~1:2000 IHC-P~~N/A FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | AXIN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AXIN2 |
|---|---|
| Function | Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in brain and lymphoblast. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
REFERENCES
Inkster, B., et al. Neuroimage (2010) In press :
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Olschwang, S., et al. J Oncol 2009, 306786 (2009) :
Dong, X., et al. Cytogenet. Cell Genet. 93 (1-2), 26-28 (2001) :
Liu, W., et al. Nat. Genet. 26(2):146-147(2000)
von Kries, J.P., et al. Nat. Struct. Biol. 7(9):800-807(2000)
Kikuchi, A. Cytokine Growth Factor Rev. 10 (3-4), 255-265 (1999) :
Mai, M., et al. Genomics 55(3):341-344(1999)
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