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AKAP7 Rabbit pAb
AKAP7 Rabbit pAb
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- 背景知识
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | O43687 |
| Reactivity | Human, Rat |
| Predicted | Mouse, Pig, Horse, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 11465 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human AKAP7 |
| Epitope Specificity | 31-80/104 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Apical cell membrane. Targeted predominantly to the apical membrane and Lateral cell membrane. Targeted predominantly to the lateral membrane. |
| SUBUNIT | Binds cAMP-dependent protein kinase (PKA). Interacts with PRKCA; only the cytoplasmic form is capable of interacting with PRKCA. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | A kinase (PRKA) anchor protein 7; A kinase anchor protein 18 kD; A Kinase Anchor Protein 7; A Kinase Anchor Protein 7 Isoform Alpha; A kinase anchor protein 7 isoform beta; A kinase anchor protein 7 isoform gamma; A kinase anchor protein 7 isoforms alpha and beta; A kinase anchor protein 9 kDa; A Kinase Anchoring Protein 18; A-kinase anchor protein 18 kDa; A-kinase anchor protein 7 isoforms alpha and beta; AKA7A_HUMAN; AKAP 18; AKAP 7; AKAP-7 isoforms alpha and beta; AKAP15; AKAP18; Akap7; HGNC377; OTTHUMP00000040266; Protein kinase A anchoring protein 7; Protein kinase A anchoring protein 7 isoform alpha; Protein kinase A anchoring protein 7 isoform beta; Protein kinase A anchoring protein 7 isoform gamma; Protein kinase A anchoring protein 7 isoforms alpha/beta; Protein kinase A-anchoring protein 7 isoforms alpha/beta. |
| Gene ID | 9465 |
|---|---|
| Other Names | A-kinase anchor protein 7 isoforms alpha and beta, AKAP-7 isoforms alpha and beta, A-kinase anchor protein 18 kDa, AKAP 18, Protein kinase A-anchoring protein 7 isoforms alpha/beta, PRKA7 isoforms alpha/beta, AKAP7, AKAP15, AKAP18 |
| Target/Specificity | Expressed in brain, heart, lung, pancreas and skeletal muscle. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | AKAP7 |
|---|---|
| Synonyms | AKAP15, AKAP18 |
| Function | Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. |
| Cellular Location | [Isoform Alpha]: Lateral cell membrane; Lipid- anchor. Note=Targeted predominantly to the lateral membrane |
| Tissue Location | Expressed in brain, heart, lung, pancreas and skeletal muscle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
A kinase (PRKA) anchor protein 7; A kinase anchor protein 18 kD; A Kinase Anchor Protein 7; A Kinase Anchor Protein 7 Isoform Alpha; A kinase anchor protein 7 isoform beta; A kinase anchor protein 7 isoform gamma; A kinase anchor protein 7 isoforms alpha and beta; A kinase anchor protein 9 kDa; A Kinase Anchoring Protein 18; A-kinase anchor protein 18 kDa; A-kinase anchor protein 7 isoforms alpha and beta; AKA7A_HUMAN; AKAP 18; AKAP 7; AKAP-7 isoforms alpha and beta; AKAP15; AKAP18; Akap7; HGNC377; OTTHUMP00000040266; Protein kinase A anchoring protein 7; Protein kinase A anchoring protein 7 isoform alpha; Protein kinase A anchoring protein 7 isoform beta; Protein kinase A anchoring protein 7 isoform gamma; Protein kinase A anchoring protein 7 isoforms alpha/beta; Protein kinase A-anchoring protein 7 isoforms alpha/beta.
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